Monday, October 3, 2011

China calls for talks over shelved Myanmar dam (Reuters)

BEIJING (Reuters) ? China called on Saturday for talks with Myanmar after the government there suspended a controversial $3.6 billion, Chinese-led dam project.

After weeks of rare public outrage against the Myitsone dam, Myanmar's largest hydropower project, President Thein Sein told parliament his government had to act "according to the desire of the people".

Myanmar's then military government proposed the dam in 2006 and signed a contract in 2009 with the Myanmar military-backed Asia World Company and China Power Investment Corp to build it.

China's Foreign Ministry said "relevant countries should guarantee the legal and legitimate rights of Chinese companies".

"The Myitsone dam is a jointly invested project between China and Myanmar, and has been ... thoroughly examined by both sides," ministry spokesman Hong Lei said in a statement on the ministry's website (www.mfa.gov.cn)

"Both sides should appropriately deal with matters related to the progress of this project through friendly consultations," he added.

The northern Myanmar dam would have flooded an area about the size of Singapore, creating a 766-square-km reservoir, mainly to serve growing energy needs in neighbouring China, which would have imported about 90 percent of its power.

In recent years, Myanmar's leaders have embraced investment from China as a deep and lucrative market for the former British colony's energy-related resources and to counterbalance the impact of Western sanctions imposed in response to human rights abuses.

But in recent weeks, the dam had become a symbol of resentment over China's growing influence and revealed a stark divide between cabinet ministers and parliamentary leaders, making it the first real public test over whether reformers or hard-liners had more sway over the country's direction.

While China and Myanmar have close economic and political ties, including the building of oil and gas pipelines into southwestern China, there are also deep mutual suspicions.

China has frequently expressed its concern at instability along their often mountainous and remote border, where rebel groups deeply involved in the narcotics trade have been fighting Myanmar's central government for decades.

Myanmar in turn looks warily at its vast neighbour, and has tried forging closer ties with India to offset China's influence.

(Reporting by Ben Blanchard; Editing by Robert Birsel)

Source: http://us.rd.yahoo.com/dailynews/rss/india/*http%3A//news.yahoo.com/s/nm/20111001/india_nm/india596525

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Sunday, October 2, 2011

It?s Been A Week Without All My Children?Sniff Sniff

It’s been a whole week since All My Children signed off last Friday, and let me tell you, I’m going through some major withdrawals. My life has centered around this show for so long, and this week I’ve felt lost without it. I know, it’s just a TV show right? Get over it, you say? Well, that’s easier said than done. Many have told me, oh come on, you can watch it online in January. Um, without the amazing Erica Kane? Susan Lucci has reportedly declined to take part in Prospect Park’s online AMC show. While some cast members have agreed to move on to the online endeavor, it simply will not be the same. Other central characters to Pine Valley have already jumped ship and signed contracts with other shows, notably Debbi Morgan (Angie), who will now appear on The Young and the Restless, and Jacob Young (J.R.), who has gone back to a role he originated on The Bold and the Beautiful. Last week’s cliffhanger finale saw J.R. wielding a gun at the Chandler mansion, where a party is being held to welcome Stuart (who was thought to be dead) home. J.R. fires off the gun, but we [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/c7OPyLVyZhM/

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Recovery next year for world stocks: poll (Reuters)

LONDON (Reuters) ? World stock markets will recover next year from a nightmarish 2011 that has wiped trillions of dollars off share prices, according to a Reuters poll that showed almost all major stock indexes ending 2011 in the red.

Darkening economic prospects and fears the euro zone debt crisis will unravel into financial catastrophe sent global stocks plummeting around 14 percent since the last quarterly poll of equity strategists in June.

Only the Dow Jones Industrial Average and South Korea's KOSPI are expected to finish the year with gains compared with 2010's closing levels, among the 19 major stock indexes covered by Reuters polls over the last week.

Still, despite the dire performance of stock markets so far this year, most respondents were stuck in their usual habit of predicting big gains, no matter what real risks face the world economy.

According to the consensus, only one index -- Taiwan's TAIEX -- is expected to finish 2011 at a significantly lower level than its close on Thursday.

The last three months have seen an enormous spike in stock market volatility, to the point that several of the survey's usual sample of around 350 analysts refused to give forecasts this time.

While analysts are waiting for clear signs either way of progress or failure in fixing the euro zone debt crisis, stalling economic growth in major Western economies will restrain share prices in coming months.

"The global slowdown will still drive economic growth and earnings lower," said Philippe Gijsels, head of research at BNP Paribas Fortis in Brussels.

"Obstacles to a new bull market are still formidable... there is a lot of political uncertainty. This will take time to clear."

World equities have already lost around $3.7 trillion dollars in market capitalization since the start of this year -- more than the nominal gross domestic product of Germany.

Even by midway through next year, analysts expect only a handful of stock indexes -- seven out of 18 -- to top their closing 2010 levels. By comparison, world stocks rose around 30 percent in 2009 and around 10 percent last year.

TOP PERFORMERS

There is at least some support for the notion that equity markets should start rising again, other than the perennial bullishness of equity market analysts.

For one thing, global shares look undervalued compared with historical averages. The MSCI World Index is currently trading a little over 10 times 12-month forward earnings, the lowest since December 2008, and considerably below the average of 14.3 over the past decade.

Investors too are entering the fourth quarter with a slightly raised exposure to shares and holding high reserves of cash that could quickly be used to fuel a stock rally, a Reuters poll showed on Thursday.

Russia's RTS index, long the darling of the poll's equity bulls, again topped the chart among indexes expected to yield the biggest returns with a 32 percent gain expected between now and mid-2012.

The Shanghai Stock Exchange should rise smartly next year after a torrid two years of heavy losses, the poll showed, while Brazil's Bovespa is expected to rally about as strongly as Russia.

"Even with the sovereign debt crisis in Europe worsening and discouraging U.S. data, we see the Brazilian economy as plenty resilient," said Paulo Esteves of Gradual Investimentos.

The survey also suggested strong gains lie ahead on some rich-world bourses, with bourses in the United States, Australia, France, Germany and Japan expected to yield double-digit returns from now until mid-2012.

"The recent sell-off in stock markets around the world, especially in Europe, has been the result of a lack of confidence, not growth," Markus Huber, head of German sales trading at ETX Capital, said.

Even so, the near-term outlook is very uncertain. The Dow Jones Industrial Average is the only developed-world index that analysts expect to finish the year in the black, with a modest gain of around 2 percent over the course of 2011.

LAGGARDS

Taiwan's TAIEX is expected to be by far the worst performing market out of the 19 indexes in the Reuters poll.

Having already lost around 20 percent of its value so far this year, analysts see the TAIEX falling a further 5 percent from now until the end of the year and almost 9 percent by mid-2012, as the tech-heavy index suffers badly from slowing exports to struggling Western economies.

The other most notable laggard was Britain's FTSE 100, one of the world's largest by capitalization, which respondents expect will register a full-year loss of around 11 percent.

The poll showed the FTSE gaining marginally between now and the end of the year, and only about 6 percent between now and mid-2012 -- considerably less than forecast for its U.S. and European peers.

"I would say that there is potential for upside on the FTSE, but I think the likelihood of any economic growth has been stunted severely by what's happening in the euro zone," said Martin Dobson, head of trading at Westhouse Securities.

(Additional reporting from reporters in London, Paris, New York, Tokyo, Shanghai, Sydney, Hong Kong, Johannesburg, Frankfurt, Milan, Sao Paulo, Toronto, Seoul, Moscow and Mumbai. Polling by Ruby Cherian and Shaloo Shrivastava in Bangalore, Analysis by Sumanta Dey and Yati Himatsingka. Editing by Ross Finley and Jon Loades-Carter)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20110929/bs_nm/us_markets_stocks_poll

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Saturday, October 1, 2011

Diabetes and cancer: A shared biological basis

Diabetes and cancer: A shared biological basis [ Back to EurekAlert! ] Public release date: 29-Sep-2011
[ | E-mail | Share Share ]

Contact: Lisa Lyons
elyons@cell.com
617-386-2121
Cell Press

Contrary to what you might think, cancer and diabetes appear to have some biology in common. According to a report in the September 30th issue of the Cell Press journal, Cell, a pathway that initially drew attention for its role in embryonic stem cells and cancer also influences the odds that mice develop or resist diabetes.

Mice with high levels of the cancer-promoting proteins Lin28a or Lin28b become more sensitive to insulin and less prone to diabetes when on a high-fat diet, the new study shows.

"This highlights the overlap in the biology of these disorders," said George Daley of Harvard Medical School. "It may be the same kinds of metabolic shifts that allow cancer cells to grow are also related to [whole-body] glucose metabolism."

In fact, there were clues about such a connection, but "no obvious mechanism," he says. For instance, studies have shown that cancer cells within a tumor are able to grow more rapidly by shifting the way they use glucose. Genome-wide association studies for type 2 diabetes have also pinpointed several susceptibility genes with known links to cancer or the cell cycle.

Daley's team, including first authors Hau Zhu and Ng Shyh-Chang, had noticed earlier that an immature form of the microRNA (tiny bits of RNA that silence genes by targeting messenger RNA) known as let-7 is abundant in stem cells. "It allows stem cells to be stem cells," Zhu says.

Let-7 is also important in preventing cancer, Zhu explained, and its activity is blocked by the cancer-promoting RNA-binding protein Lin28. Lin28 is also known as an ingredient that can help turn skin cells into embryonic stem cell-like cells.

"Mice with too much Lin28 grow really large," Zhu said based on their earlier work. "They are giant mice and they soak up glucose really efficiently." The new study shows that Lin28 transgenic mice are also resistant to diabetes and obesity. That resistance holds even as the mice grow older, said Shyh-Chang.

Mice lacking Lin28a or that have increases in let-7 become insulin resistant and have impaired glucose tolerance. These metabolic changes occurred in part through effects linked to the insulin-PI3K-mTOR pathway, which is important in cancer and basic metabolism.

Importantly, the researchers also found that let-7 acts on many genes with apparent links to type 2 diabetes and glucose control in humans. This may prove to be good news for those in search of new ways to tackle complex conditions like diabetes, which have many genetic drivers, each with relatively small effects.

"MicroRNAs touch multiple targets in subtle ways," Shyh-Chang said. "Our findings suggest that let-7 and perhaps other microRNAs may help to unify the picture of how type 2 diabetes develops."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Diabetes and cancer: A shared biological basis [ Back to EurekAlert! ] Public release date: 29-Sep-2011
[ | E-mail | Share Share ]

Contact: Lisa Lyons
elyons@cell.com
617-386-2121
Cell Press

Contrary to what you might think, cancer and diabetes appear to have some biology in common. According to a report in the September 30th issue of the Cell Press journal, Cell, a pathway that initially drew attention for its role in embryonic stem cells and cancer also influences the odds that mice develop or resist diabetes.

Mice with high levels of the cancer-promoting proteins Lin28a or Lin28b become more sensitive to insulin and less prone to diabetes when on a high-fat diet, the new study shows.

"This highlights the overlap in the biology of these disorders," said George Daley of Harvard Medical School. "It may be the same kinds of metabolic shifts that allow cancer cells to grow are also related to [whole-body] glucose metabolism."

In fact, there were clues about such a connection, but "no obvious mechanism," he says. For instance, studies have shown that cancer cells within a tumor are able to grow more rapidly by shifting the way they use glucose. Genome-wide association studies for type 2 diabetes have also pinpointed several susceptibility genes with known links to cancer or the cell cycle.

Daley's team, including first authors Hau Zhu and Ng Shyh-Chang, had noticed earlier that an immature form of the microRNA (tiny bits of RNA that silence genes by targeting messenger RNA) known as let-7 is abundant in stem cells. "It allows stem cells to be stem cells," Zhu says.

Let-7 is also important in preventing cancer, Zhu explained, and its activity is blocked by the cancer-promoting RNA-binding protein Lin28. Lin28 is also known as an ingredient that can help turn skin cells into embryonic stem cell-like cells.

"Mice with too much Lin28 grow really large," Zhu said based on their earlier work. "They are giant mice and they soak up glucose really efficiently." The new study shows that Lin28 transgenic mice are also resistant to diabetes and obesity. That resistance holds even as the mice grow older, said Shyh-Chang.

Mice lacking Lin28a or that have increases in let-7 become insulin resistant and have impaired glucose tolerance. These metabolic changes occurred in part through effects linked to the insulin-PI3K-mTOR pathway, which is important in cancer and basic metabolism.

Importantly, the researchers also found that let-7 acts on many genes with apparent links to type 2 diabetes and glucose control in humans. This may prove to be good news for those in search of new ways to tackle complex conditions like diabetes, which have many genetic drivers, each with relatively small effects.

"MicroRNAs touch multiple targets in subtle ways," Shyh-Chang said. "Our findings suggest that let-7 and perhaps other microRNAs may help to unify the picture of how type 2 diabetes develops."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-09/cp-dac092311.php

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